Keep an eye on for signs of urinary retention or lowered gastric motility if oliceridine is coadministered with anticholinergics.
iloperidone raises levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is really a time-dependent CYP3A inhibitor and may produce enhanced plasma levels of drugs predominantly eradicated by CYP3A4.
Take into consideration reducing the dose of those prescription drugs when presented coadministered with methylphenidate. Keep an eye on for drug toxiticities when initiating or discontinuing methylphenidate.
drospirenone will enhance the degree or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Mitotane is a robust inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for achievable dosage adjustments.
armodafinil will lessen the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Indicated for acute treatment method of intermittent, stereotypic episodes of Regular seizure exercise (ie, seizure clusters, acute repetitive seizures) distinctive from a individual’s regular seizure sample Utilized adjunctively in convulsive Issues, even though it hasn't proved practical as the sole therapy
Challenges of dependence and withdrawal enhance with longer cure period and better each day dose; While injection is indicated only for intermittent use, if applied additional regularly than encouraged, abrupt discontinuation or immediate dosage reduction may well precipitate acute
Use Caution/Keep track of. Ethinyl estradiol could inhibit the clearance of benzodiazepines that undergo oxidation, therefore raising serum concentrations of concomitantly administered benzodiazepines.
Put client on side experiencing you with higher leg bent ahead, lubricate rectal applicator tip, Carefully insert syringe idea in rectum and bit by bit drive plunger
VALTOCO provides a similar diazepam since the rectal gel trustworthy by care associates, with no unpleasant shipping and delivery.
Usage of benzodiazepines, together with diazepam, both equally utilized alone and together with other CNS depressants, may bring on perhaps lethal respiratory melancholy
diazepam improves toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Keep an eye on Carefully. Experiments have shown that the combination of benzodiazepines and buprenorphine altered the same old ceiling impact on buprenorphine-induced respiratory depression, generating the respiratory results of buprenorphine look just like These of complete opioid agonists.
Having heroin while you take prescribed dihydrocodeine is get more info particularly hazardous. You happen to be more prone to get all the Negative effects of dihydrocodeine, including addiction.